J. KOJI LUM

Email: klum@binghamton.edu

(PhD University of Hawai'i 1995), Associate Professor of Anthropology and Biological Sciences, Director of LEAH (Laboratory of Evolutionary Anthropology and Health), is a molecular anthropologist and population geneticist whose research focuses on the origins, interactions, and resulting genetic characteristics of Pacific Island populations. Other research interests include the evolution of Plasmodium falciparum drug resistance (NIH RO1 funded), malaria epidemiology in Melanesia and Africa, ancient DNA, forensic genetics, animal and plant domestication, ecosystem population genetics, the interaction between infectious and chronic diseases, neurotransmitter polymorphisms and behavior, and molecular evolution.

Scientific Publications

Lum JK, A Kaneko, G Taleo, M Amos, DM Reiff (in press) Genetic diversity and gene flow of humans, Plasmodium falciparum, and Anopheles farauti s.s. of Vanuatu: Inferred malaria dispersal and implications for malaria control. Acta Tropica

Reiff DM, A Kaneko, G Taleo, M Amos, JK Lum (in press) Population structure and gene flow of Anopheles farauti (Diptera Culicidae) among ten sites on five islands of Vanuatu: Implications for malaria control. Journal of Medical Entomology

Eisenberg DTA, J MacKillop, M Modi, J Beauchemin, D Dang, SA Lisman, JK Lum and DS Wilson (2007) Examining Impulsivity as an Endophenotype Using a Behavioral Approach: A DRD2 TaqI A and DRD4 48-bp VNTR Association Study. Behavioral and Brain Functions 3:2

Lum JK, JK McIntyre, DL Greger, KW Huffman, and MG Vilar (2006) Recent Southeast Asian domestication and Lapita dispersal of sacred male pseudohermaphroditic “tuskers” and hairless pigs of Vanuatu. Proceedings of the National Academy of Sciences USA 103:17190-17195

Chan CW, RM Garruto, JK Lum (2006) Paleoparasite populations from archived sera: Insights into Chloroquine drug resistance in Papua New Guinea. J Infect Dis194:1023-1024

Chan CW, D Lynch, R Spathis, RM Garruto, and JK Lum (2006) Flashback to the 60s: Utility of archived sera to explore the origin and evolution of Plasmodium falciparum chloroquine resistance in the Pacific. Acta Tropica 99:15-22

Mita T, Kaneko A, Hombhanje F, Hwaihwanje I, Takahashi N, Osawa H, Tsukahara T, Masta A, Lum JK, Kobayakawa T, Ishizaki T, Bjorkman A. (2006) Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New Guinea. Acta Trop. 98:137-44

Tsukahara T, FW Hombhanje, JK Lum, I Hwaihwanje, A Masta, A Kaneko, and T Kobayakawa (2006) Austronesian origin of the 27 base pair deletion of the erythrocyte band 3 gene in East Sepik, Papua New Guinea inferred from mtDNA analysis. Journal of Human Genetics 51:244-248

Ubalee, R, T Tsukahara, M Kikuchi, JK Lum, M Dzodzomenyo, A Kaneko, and K Hirayama (2005) TNF-a promoter polymorphism and malaria in Vanuatu. Tropical Medicine and International Health 10:544-549

Hombhanje FW, I Hwaihwanje, T Tsukahara, J Saruwatari, M Nakagawa, H Osawa, MM Paniu, N Takahashi, JK Lum, B Aumora, A Masta, M Sapuri, T Kobayakawa, A Kaneko, and T Ishizaki (2005) The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria. British Journal of Clinical Pharmacology 59:298-301

Akhwale, WS, JK Lum, A Kaneko, H Eto, C Obonyo, A Björkman, and T Kobayakawa (2004) Anemia and unstable malaria at different altitudes in the western highlands of Kenya. Acta Tropica 91:167-175

Mita, T, A Kaneko, JK Lum, IL Zungu, T Tsukahara, H Eto, T Kobayakawa, A Björkman, and K Tanabe (2004) Expansion of wild type allele rather than back mutation in Pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi. Molecular Biochemistry and Parasitology 135:159-163

Cann, RL and JK Lum (2004) Dispersal Ghosts in Oceania. Am J Hum Biol, 16:1-12

Wirth, T, X Wang, RP Novick, JK Lum, M Blaser, D Falush, and M Achtman (2004) Deciphering recent human history via sequencesfrom Helicobacter pylori: lessons from the Ladakh. Proceedings of the National Academy of Sciences USA, 101:4746-4751

Lum, JK, A Kaneko, K Tanabe, N Takahashi, A Björkman, and T Kobayakawa (2004) Malaria dispersal among islands: human and Plasmodium falciparum gene flow in Vanuatu. Acta Tropica, 90:181-185

Masta, A, JK Lum, T Tsukahara, I Hwaihwanje, A Kaneko, MM Paniu, M Sapuri, N Takahashi, T Ishizaki, T Kobayakawa, and FW Hombhanje (2003) Analysis of Sepik populations of Papua New Guinea suggests an increase of CYP2C19 null allele frequencies during the colonization of Melanesia. Pharmacogenetics, 13:697-700

Yusuf, I, MW Djojosubroto, R Ikawati, K Lum, A Kaneko, and S Marzuki (2003) Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia. Adv Exp Med Biol, 531:37-46

Mita, T, A Kaneko, JK Lum, B Bwijo, M Takechi, IL Zungu, T Tsukahara, T Kobayakawa, K Tanabe, and A Bjorkman (2003) Recovery of chloroquine sensitivity and low prevalence of pfcrt K76T following the withdrawal of chloroquine in Malawi. American Journal of Tropical Medicine and Hygiene 68:413-415

Bwijo, B, A Kaneko, M Takechi, IL Zungu, Y Moriyama, JK Lum, T Tsukahara, T Mita, N Takahashi, Y Bergqvist, A Björkman, and T Kobayakawa (2003a) High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi. Acta Tropica, 85:363-373

Bwijo, B, A Kaneko, JK Lum, IL Zungu, T Tsukahara, T Mita, and T Kobayakawa (2003b) Antimalarial Drug Efficacy in Plasmodium falciparum Infections in Malawi, Seven Years After Switching From Chloroquine to Sulfadoxine/pyrimethamine. Journal of Tokyo Women's Medical University, 73:1-13

Lum, JK, LB Jorde, and W Schiefenhovel (2002) Affinities among Melanesians, Micronesians, and Polynesians: a neutral, biparental genetic perspective. Human Biology 74(3): 413-430

Ciminelli BM, F Pompei1, M Relucenti, JK Lum, J Simpore, G Spedini, C Martínez- Labarga, and M Pardo (2002) Confirmation of the potential usefulness of two human beta globin pseudogene markers to estimate gene flows to and from sub- saharan Africans. Human Biology,74(2): 243-252

Bwijo, B, A Kaneko, T Tsukahara, M Takechi, JK Lum, and T Kobayakawa (2001) Findings of decreased chloroquine resistance in Plasmodium falciparum isolates of Malawi. Clinical Parasitology, 12: 145-147

Handoko, HY, JK Lum, Gustiani, Rismalia, H Kartapradja, ASM Sofro, and S Marzuki (2001) Length variations in the COII-tRNALys intergenic region of mitochondrial DNA in Indonesian populations. Human Biology, 73(2): 205-223

Lum, JK (2001) Comment to Terrell, JE, KM Kelly, and P Rainbird. Forgone conclusions? An analysis of the concepts of "Austronesians" and "Papuans". Current Anthropology, 42: 97-124

Lum, JK and RL Cann (2000) mtDNA lineage analyses: origins and migrations of Micronesians and Polynesians. American Journal of Physical Anthropology, 113(2): 151-168

Lum, JK, M Nikaido, M Shimamura, H Shimodaira, AM Shedlock, N Okada, and M Hasegawa. (2000) Consistency of SINE insertion topology and flanking sequence tree: Quantifying relationships among Cetartiodactyls. Molecular Biology and Evolution, 17(10):1417-1424

Weisler, M, JK Lum, S Collins, and W Kimoto (2000) Status, health, and ancestry of a late prehistoric burial from Kwajalein Atoll, Marshall Islands. Micronesica, 32: 191-200

Kaneko, A, JK Lum, J Yaviong, Y Takahashi, T Ishizaki, L Bertilsson, T Kobayashi, and A Bjorkman (1999) High and variable frequencies of CYP2C19 mutations:  medical consequences of poor drug metabolism in Vanuatu and other Pacific islands. Pharmacogenetics, 9(5): 581-590

Rickards, O, C Martinex-Labarga, JK Lum, GF De Stefano, and RL Cann (1999) Mitochondrial DNA history of the Cayapa Amerinds of Ecuador: detection of additional founding lineages for the native American populations. American Journal of Human Genetics, 65(2): 519-530

Watkins, WS, M Bamshad, ME Dixon, B Bhaskara Rao, JM Naidu, PG Reddy, BVR Prasad, PK Das, PC Reddy, PB Gai, A Bhanu, YS Kusuma, JK Lum, P Fischer, and LB Jorde (1999) Multiple origins of the mtDNA 9-bp deletion in populations of South India. American Journal of Physical Anthropology, 109(2): 147-158

Sugimura, H, T Kohno, K Wakai, K Nagura, K Genka, H Igarashi, BJ Morris, S Baba, Y Ohno, CM Gao, ZY Li, JD Wang, T Takezaki, K Tajima, T Varga, T Sawaguchi, JK Lum, JJ Martinson, S Tsugane, T Iwamasa, K Shinmura, J Yukota (1999) hOGG1 Ser326Cys polymorphism and lung cancer susceptibility. Cancer Epidemiology, Biomarkers and Prevention, 8: 669-674

Lum JK, RL Cann, JJ Martinson, and LB Jorde (1998) Mitochondrial and nuclear genetic relationships among Pacific island and Asian populations. American Journal of Human Genetics, 63(2): 613-624
Lum, JK (1998) Central and Eastern Micronesia: Genetics, the overnight voyage, and linguistic divergence. Man and Culture in Oceania, 14: 69-80

Lum, JK, and RL Cann (1998) mtDNA and language support a common origin of Micronesians and Polynesians in island Southeast Asia. American Journal of Physical Anthropology, 105: 109-119
Cann, RL, and JK Lum (1996) Mitochondrial myopia: Reply to Bonatto et al. American Journal of Human Genetics, 59: 256-258

Lum, JK, O Rickards, C Ching, and RL Cann (1994) Polynesian mitochondrial DNAs reveal three deep maternal lineage clusters. Human Biology, 66(4): 567-590

Book Chapters

Lum JK (2007) Contributions of population origins and gene flow to the diversity of neutral and malaria selected autosomal genetic loci of Pacific Island populations. In: Genes, language, and culture history in the Southwest Pacific. J Friedlaender ed. Oxford University Press

Yusuf, I, MW Djojosubroto, R Ikawati, K Lum, A Kaneko, and S Marzuki (2003) Ethnic and Geographical Distributions of CYP2C19 Alleles in the Populations of Southeast Asia. In: Tropical Diseases: From Molecule to Bedside. S Marzuki ed. Kluwer Academic Pub

Lum, JK (2001) The colonization of Remote Oceania and the drowning of Sundaland. in: Genetic, Linguistic and Archaeological Perspectives on Human Diversity in Southeast Asia. M Seielstad, L Jin, and C Xiao eds. World Scientific Publishing Co.

Cann, RL, and JK Lum (1996) Mankind and Pacific biogeography. pp 437-443. in: Pacific Island Biotas, edited by R Keast, SPB Academic Publishing, Amsterdam

Cann, RL, O Rickards, and JK Lum (1994) Mitochondrial DNA and human evolution: Our one lucky mother. pp 136-147. in: Origin of anatomically modern humans, edited by M Nitecki, University of Chicago Press, Chicago

Cann, RL, R Feldman, LA Freed, JK Lum, and C Reeb (1993) Collection and storage of vertabrate materials for molecular evolutionary studies. pp 38-51. in: Methods in Enzymology vol.224, Molecular evolution: producing the biochemical data, edited by Zimmer, EA, TJ White, RL Cann, and AC Wilson, executive editors Abelson, JN and MI Simon

Reports

Lum, JK and GM Heathcote (1998) Genetic relationships of Micronesian populations: A project update. Version 1: For General Distribution. Paper Number 1, Non-Technical Report Series, Anthropology Resource & Research Center, University of Guam

Course for the Spring 2008 Semester: ANTH 559

 

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